Biomedical Engineering Reference
In-Depth Information
Chapter 5
Optical Waveguide-Based Biosensors
Using Noble Metal Nanoparticles
Lai-Kwan Chau,
a,b,
*
Chang-Yue Chiang,
a
Wei-Ting Hsu,
a
Shin-Huei
Chen,
a
and Shu-Fang Cheng
a
a
Department of Chemistry and Biochemistry, National Chung Cheng University,
168 University Road, Min-Hsiung, Chia-Yi 621, Taiwan
b
Center for Nano Bio-Detection, National Chung Cheng University,
168 University Road, Min-Hsiung, Chia-Yi 621, Taiwan
*
chelkc@ccu.edu.tw
The particle plasmon resonance (PPR) property of noble metal
nanoparticles allows label-free and real-time detection of
biomolecules. To enhance the signal derived from this property, the
use of optical waveguide sensing technology further increases the
sensitivity of the PPR biosensing technique. The optical waveguides
described in this chapter include optical iber, planar waveguide, and
tubular waveguide. The principle for this improvement is discussed.
5.1 Introduction
The development of biosensors for medical diagnostics,
1
drug
discovery,
2
monitoring of food safety,
3
agricultural diagnostics,
4
bioprocess monitoring,
5
environmental monitoring,
6
and detection
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