Biomedical Engineering Reference
In-Depth Information
Chapter 4
Slide- and Micoarray-Based Biosensors
Using Noble Metal Nanoparticles
Ping-Ji Huang
a,c
and Lai-Kwan Chau
a,b,
*
a
Department of Chemistry and Biochemistry, National Chung Cheng University,
168 University Road, Min-Hsiung, Chia-Yi 621, Taiwan
b
Center for Nano Bio-Detection, National Chung Cheng University,
168 University Road, Min-Hsiung, Chia-Yi 621, Taiwan
c
Institute of Nuclear Energy Research, Atomic Energy Council,
1000 Wenhua Road, Chiaan Village, Lungtan, Taoyuan 325, Taiwan
*
chelkc@ccu.edu.tw
Localized surface plasmon resonance (LSPR) excitation in noble
metal nanoparticles (
NMNPs
) produces strong extinction spectra
that in recent years have been used for chemical and biological
sensing. This chapter describes recent developments in LSPR
sensing that utilize key relationships governing the LSPR spectra,
particularly wavelength shift, and their sensitivity to the local
environment, including particle size and shape. Since the detection
process is based on the change of refractive index of the surrounding
medium when the analyte interacts with a molecular group on the
nanoparticle surface, the sensor is label free.
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