Biomedical Engineering Reference
In-Depth Information
Chapter 11
Surface-Enhanced Raman Scattering
Based on Noble Metal Nanoparticles
Li-Lin Tay
*
and John E. Hulse
National Research Council Canada, 1200 Montreal Road,
Ottawa Ontario K1A0R6, Canada
*
lilin.tay@nrc-cnrc.gc.ca
Surface-enhanced Raman scattering (SERS) is a powerful spectro-
scopic technique that leverages the enormous electromagnetic
ield enhancement caused by the excitation of an intense, sharp
and localized surface plasmon resonance of metal nanostructures.
The effect can provide rich structural and chemical information
for molecules adsorbed on or bonded to SERS active nanometer-
sized metal structures. Recent advances in nanotechnology and
nanofabrication techniques have enabled researchers to design
SERS active colloidal nanoparticle (NP) systems with optimized
electromagnetic enhancements engendering a large variety of SERS-
based bioanalytical and bioimaging applications. The advantages of
SERS over standard luorescent labeling techniques lie not only in its
multiplexing capability and superior photostability, but also in the
potential multimodal functionality provided by the other intrinsic
properties of the metal NPs, such as the photothermal response
which enable its therapeutic role in the treatment of cancer.
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