Biomedical Engineering Reference
In-Depth Information
Chapter 8
Biodetection Based on Resonance Light
Scattering of Noble Metal Nanoparticles
Tai-Chia Chiu and Cho-Chun Hu
Department of Applied Science, National Taitung University,
684, Section 1, Chunghua Road, Taitung 95002, Taiwan
tcchiu@nƩu.edu.tw, cchu@nƩu.edu.tw
Gold nanoparticles (Au NPs) and silver nanoparticles (Ag NPs)
are two of the most eficient light scattering materials, and are
extensively utilized in resonance light scattering (RLS) techniques.
RLS techniques using these NPs are sensitive and selective for the
analysis of biological and environmental samples. Although Au
NPs are not as eficient as Ag NPs in RLS, their stability, ease in
preparation and conjugation make them more popular. Because
RLS signals are proportional to aggregate size, most RLS techniques
are developed from measuring the RLS signal based on the
aggregation of Au or Ag NPs, induced by the analytes. To develop
highly sensitive RLS techniques, several important parameters
such as the nature, size, and shape of NPs, as well as the intensity
and frequency of the light source must be well controlled. Due to
signiicant progress in nanoscience, it is expected that more eficient
RLS probes will soon be developed for the detection of trace
biomolecules and cell imaging.
Search WWH ::
Custom Search