Biomedical Engineering Reference
In-Depth Information
are suitable carriers for enzymatic and DNA hybridization assays. In
addition, when luorophores are tagged on the functional moieties,
the strong interactions between the nanoparticle surface electrons
and luorophore dipoles can facilitate ultra-sensitive luorescence
detection methods such as FRET and SPCE. Functionalized
nanoparticles can be coated on the microchannel surfaces or illed
into running solutions to be employed with microluidic devices.
Similarly, micro-mixing is helpful for improving slow diffusivity
problems of targeted molecules.
Other types of assays using noble metal nanoparticles such as
SERS and thermal lens based methods have also been reported to
perform in microchannels.
Acknowledgment
This work was supported by the National Science Council, Taiwan.
References
1. P. Fortina, D. Graves, C. Stoeckert, Jr., S. McKenzie, and S. Surrey, in
Biochip Technology , Eds. J. Cheng and L. J. Kricka, (Harwood Academic
Publishers, Philadelphia, 2001), p. 185.
2. P. S. Dittrich, K. Tachikawa, and A. Manz, Anal . Chem ., 78 , 3887 (2006).
3. J. West, J. Becker, M. Tombrink, and A. Manz, Anal . Chem ., 80 ,
4403 (2008).
4. M. J. Felton, Anal . Chem ., 75 , 505A (2003).
5. M. J. Madou, Fundamentals of Microfabrication: The Science of.
Miniaturization, (Taylor & Francis, New York, 2002).
6. S. C. Jacobson, R. Hergenroder, L. B. Koutny, R. J. Warmack, and J. M.
Ramsey, Anal . Chem ., 66 , 1107 (1994).
7. D. Solignac, A. Sayah, S. Constantin, R. Freitag, and M. A. M. Gijs, Sensors
Actuators , 92 , 388 (2001).
8. T. D. Boone, Z. H. Fan, H. H. Hooper, A. J. Ricco, H. Tan, and S. J. Williams,
Anal . Chem ., 78A (2002).
9. C. G. Khan Malek, Anal . Bioanal . Chem ., 385 , 1351 (2006).
10. C. G. Khan Malek, Anal . Bioanal . Chem ., 385 , 1362 (2006).
11. H. Becker, and C. Gärtner, Electrophoresis , 21 , 12 (2000).
12. J. C. McDonald, and G. M. Whitesides, Acc . Chem . Res ., 35 , 491 (2002).
 
Search WWH ::




Custom Search