Biomedical Engineering Reference
In-Depth Information
FIGURE 3.4
Different.types.of.targeting.
3.5.1.1.3 Drug Release
Drug.release.can.occur.as.a.result.of.internal.or.external.stimuli..An.example.of.an.internal.
stimulus.for.intracellular. drug. release. is. glutathione. (GSH)..The.intracellular. concentra-
tion.of.GSH.is.1-10.mM,.while.the.plasma.concentration.is.2.μM.
89
.This.vast.concentration.
difference.is.utilized.for.intracellular.drug.release,.via.place.exchange.between.GSH.and.
thiols,.which.does.not.occur.extracellularly.due.to.insuficient.GSH.concentrations.
