Biomedical Engineering Reference
In-Depth Information
1 cm
(a)
(b)
COLOR FIGURE 4.5
Three-dimensional. (3D). neovascular. maps. in. Vx-2. tumors.. With. MRI. and. α
ν
β
3
-targeted. nanoparticles,. areas.
of. angiogenesis. surrounding. Vx-2. tumors. can. be. highlighted. (dark. blue). on. 3D. mesh. models. of. the. tumor.
(digitally. resected. from. the. 3D. image. data. set).. These. two. tumors. are. the. same. age,. but. tumor. (a). received.
antiangiogenic.therapy.through.α
ν
β
3
-targeted.fumagillin-laden.theragnostic.nanoparticles.16.days.prior.to.this.
imaging. and. is. much. smaller. than. tumor. (b),. which. received. only. drug-free. particles. for. imaging.. Note. the.
heterogeneous.distribution.of.neovasculature.around.both.the.treated.and.nontreated.tumor..(Reprinted.with.
permission.from.Winter,.P.M.
,
et.al.,.
Faseb J
,.22,.2758-2767,.2008.)
c
d
e
400 nm
100 nm
100 nm
Plasmon energy (eV)
b
f
3.5
3.0
2.5
2.0
1.5
1.0
0.5
UV
Visible
Near infrared
Mid infrared
400
500 600 800
1,000
3,000 9,000
Ag nanospheres
Wavelength (nm)
50 nm
20 nm
Au nanospheres
Nanoshells, nanoegg
a
g
Nanorods
Triangles
Cubes
Nanorice
50 nm
COLOR FIGURE 5.2
Nanoparticle.resonance.range.of.plasmon.resonances.for.a.variety.of.particle.morphologies..(©.2007.Macmillan.
Publisher's.Ltd..Used.with.permission.).TEM.images.of.©.2004.(Au.spheres.(b)),.©.1995.(Ag.spheres.(a)),.and.©.
2001(SiO
2/
Ag.(core-shell).nanoshells.(c)),.and.SEM.images.of.©.2007.(nanorods.(d)),.©.2006.(cubes.(e).and.nano-
rices.(g)),.American.Chemical.Society.and.©.2006.(triangles.(f))..(Wiley-VCH..Used.with.permission.)
