Biomedical Engineering Reference
In-Depth Information
23
Electrospi
nninginDrugDelivery
PittSupaphol
1
,OrawanSuwantong
2
,andPakakrongSansanoh
1
1
ThePetroleumandPetrochemicalCollege,ChulalongkornUniversity,Pathumwan,Bangkok,Thailand
2
SchoolofScience,MaeFahLuangUniversity,Tasud,Muang,ChangRai,Thailand
CONTENTS
23.1. Introduction.to.Electrospinning..................................................................................... 455
23.2. Electrospinning.Process.and.Variables......................................................................... 456
23.2.1. Process.Parameters............................................................................................. 457
23.2.1.1. Applied.Voltage................................................................................. 457
23.2.1.2. Polymer.Flow.Rate............................................................................ 457
23.2.1.3. Capillary-Collector.Distance........................................................... 457
23.2.2. System.Parameters............................................................................................. 458
23.2.2.1. Polymer.Concentration..................................................................... 458
23.2.2.2. Solvent.Volatility............................................................................... 458
23.2.2.3. Solution.Conductivity....................................................................... 458
23.3. Electrospinning.in.Drug.Delivery.Applications.......................................................... 459
23.3.1. Biological.Active.Agents.................................................................................... 459
23.3.1.1. Anticancer.Drugs.............................................................................. 459
23.3.1.2. Anti-Inlammatory.Drugs................................................................ 461
23.3.1.3. Antibiotic.Drugs................................................................................ 463
23.3.1.4. Vitamins............................................................................................. 464
23.3.1.5. Proteins............................................................................................... 464
23.3.2. Herbal.Substances.............................................................................................. 467
23.3.3. Genes.................................................................................................................... 470
23.4. Conclusions....................................................................................................................... 471
References..................................................................................................................................... 471
23.1 IntroductiontoElectrospinning
Over. the. past. decade. electrospinning,. or. the. electrostatic. spinning. technique,. has. been.
recognized.as.the.most.promising.method.used.for.fabricating.continuous.ibers.on.a.large.
scale,.with.diameters.adjustable.from.microns.down.to.nanometers,.to.form.a.nonwoven.
or.alignment.structure..The.irst.publication.of.this.process.was.originally.pioneered.by.
Formhals. in. 1934.
1
. Despite. these. early. discoveries,. the. procedure. was. not. utilized. com-
mercially.until.2003,.as.a.part.of.the.nonwoven.industry.for.ilter.applications.
2
.In.contrast.
to.conventional.iber.production,.like.dry.spinning.and.melt.spinning,.electrospinning.is.
a.relatively.simple.and.versatile.method.to.produce.nanoibers,.driven.by.the.coloumbic.
455
