Biomedical Engineering Reference
In-Depth Information
TABLE 11.4
Characteristics.of.Commercially.Available.Liposomal.Products
TradeName,BioactiveAgent,Type
ofDosageForm,Company
Phospholipidsand
Drug/LipidRatio
Liposome
Type
Particle
Size
References
AmBisome ® ,.amphotericin.B,.
freeze-dried.liposomes,.Gilead.
Sciences/Fujisawa.Healthcare
HSPC
DSPG
CHOL
α-Tocopherol
Drug:lipid.1:6.(w:w)
SUV
.<100.nm
58,.59
Albelcet ® ,.amphotericin.B,.liposomal.
suspension,.Enzon
DMPC
DMPG
Drug:lipid.1:1.molar
MLV
<5.μm
60
DaunoXome ® ,.daunorubicin,.
liposomal.suspension,.Gilead.
Sciences
DSPC
CHOL
Drug:lipid.18.7:1.(w:w)
SUV
ca..45.nm
61
Doxil ® ,.doxorubicin,.liposomal.
suspension,.J&J.ALZA
MPEG-DSPE
HSPC
Drug:lipid.1:6.(w:w)
LUV
100.nm
62
Myocet ® ,.doxorubicin,.liposomal.
suspension,.Elan
Egg-PC
CHOL
Drug:lipid.1:4.(w:w)
MLV
.180.nm
63
Visudyne™,.Verteporin ® ,.
benzoporphyrin,.freeze-dried.
liposomes,.QLT/Novartis
Egg-DMPC
Ascorbyl.palmitate
BHT
Drug:lipid.1:7.5-15.(w:w)
SUV
<100.nm
64
Abbreviations: . SUV,. small. unilamellar. vesicle;. MLV,. multilamellar. vesicle;. LUV,. large. unilamellar. vesicle;. HSPC,.
hydrogenated.soy.phosphatidyl.choline;.PC,.phosphatidyl.choline;.DSPG,.distearoylphosphatidyl.glycerol;.
CHOL,. cholesterol;. DSPC,. distearoylphosphatidyl. choline;. PG,. phosphatidyl. glycerol;. DMPC,. dimyris-
toylphosphatidyl.choline;.MPEG-DSPE,.N-(carbonylmethoxypoly(ethylene.glycol).2000)-1,.2-distearoyl-sn-.
glycero-3-phosphoethanolamine;.BHT,.butylated.hydroxytoluene.
11.2.1.2.2 In Cosmetics
In. cosmetics,. liposomes'. moisturizing. and. restoring. properties. are. generally. exploited..
The.irst.liposomal.cosmetic.products,.Capture.(C..Dior).and.Niosomes.(L'Oréal),.were.intro-
duced. in. 1987.. Today,. many. more. liposome-containing. products,. such. as. Hydra-Radiance.
Liposome.Cream.(Avon),.Revision.Liposomal.Cream.(Revision.SkinCare),.and.Lipolow.Forte.
plus C.(Lipolow),.have.been.developed.and.are.sold.in.the.marketplace..Liposomal.cosmetic.
products.are.used.for.hydrating.skin,.reducing.skin.dryness.(the.main.reason.for.aging.and.
wrinkles),. and. replacing. skin. lipids. 56 . Liposomes. are. also. known. to. contain. recombinant.
proteins.for.wound.or.sunburn.healing..Not.only.antiaging.skin.creams,.but.also.unrinsable.
sunscreens,.long-lasting.perfumes,.hair.conditioners,.aftershaves,.and.similar.products.have.
liposomes.in.their.formulations..Table 11.5.shows.some.of.these.products. 66
Liposomes.provide.many.advantages.in.cosmetic.products,.such.as.shorter.application.
periods,.decreased.side.effects,.delayed.washing.out.(water.resistant),.increased.skin.hydra-
tion,.and.increased.penetration.into.the.deeper.layers.of.the.epidermis.that.are.absorbed.
in,.etc.
At.our.research.center.(BIOMATEN),.different.types.of.liposomes.are.being.developed.
recently.. In. one. study. dehydration-rehydration. vesicles. (DRVs). were. developed. for. use.
as.a.drug.delivery.system.to.achieve.personalized.treatment.of.patients.with.dermal.ail-
ments.such.as.sunburn.and.psoriasis. 67 .DRVs.were.selected.because.they.have.a.speciic.
 
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