Biomedical Engineering Reference
In-Depth Information
1
SP1Protein-GoldNanoparticleHybrids
asBuildingBlocksforNanofabrication
of
One-Di
mensionalSystems
IzharMedalsy,
1
OrDgany,
2
ArnonHeyman,
2
OdedShoseyov,
2
MukhlesSowwan
3
,andDannyPorath
1
1
InstituteofChemistryandCenterforNanoscienceandNanotechnology,
TheHebrewUniversityofJerusalem,Jerusalem,Israel
2
The Robert H. Smith Institute of Plant Sciences and Genetics in Agriculture, Faculty of Agriculture
Food, and Environment, The Hebrew University of Jerusalem, Rehovot, Israel
3
NanotechnologyResearchLaboratory,AlQudsUniversity,EastJerusalem,Israel
CONTENTS
1.1. Introduction............................................................................................................................. 1
1.2. The.SP1-GNP.Hybrid............................................................................................................. 2
1.3. SP1-GNP-DNA.Tri-Block.Conjugates.................................................................................. 4
1.4. SP1-GNP.Tubes....................................................................................................................... 6
1.5. Summary................................................................................................................................. 9
Acknowledgments........................................................................................................................... 9
References......................................................................................................................................... 9
1.1 Introduction
One. of. the. main. challenges. within. the. realm. of. nanoscience. and. nanotechnology. is. to.
fabricate. wires. where. the. internal. structure. along. the. wires. can. be. well. controlled. and.
manipulated.
1-5
. These. structures. hold. the. potential. of. miniaturizing. current. devices. by.
embedding.the.computational.unit.within.the.wire.
6
.Examples.of.other.one-dimensional.
(1D). structures. are. DNA. molecules. and. 1D. crystals. like. nanotubes. made. of. carbon. or.
silicon.
7-9
.These.structures.have.several.drawbacks;.DNA.was.proven.to.conduct.only.over.
short.segments,
10,11
.while.the.1D.crystals.usually.have.homogeneous.structure.and.there-
fore. lack. recognition. and. structural. manipulation. capabilities.
12
. Self-assembly. of. wires.
made.of.suitable.building.blocks.that.enable.structuring.and.well-deined.formation.can.
be.an.attractive.alternative.route.to.overcome.these.limitations..The.building.blocks.can.be.
used.to.connect.short.DNA.segments.or.form.by.themselves.conductive.wires..Candidates.
to.serve.as.building.blocks.must.demonstrate.durability.and.a.well-controlled.structure.
Proteins.can.serve.as.useful.building.blocks.for.nanoelectronic.implementations,.among.
other.reasons.because.of.the.ability.to.modify.their.structure.using.genetic.engineering.
13
.
Such.manipulations.enable.optimization.of.the.desired.building.block.properties,.such.as.
self-assembly.and.selective.attachment.of.various.nanoparticles.
14,15
.One.of.the.drawbacks.
1
