Biomedical Engineering Reference
In-Depth Information
. 47.. Iannello,.A.,.and.Ahmad,.A.,.Role.of.antibody-dependent.cell-mediated.cytotoxicity.in.the.efi-
cacy. of. therapeutic. anti-cancer. monoclonal. antibodies,.
Cancer and Metastasis Reviews
. 24. (4),.
487-499,.2005.
. 48.. Imai,.K.,.and.Takaoka,.A.,.Comparing.antibody.and.small-molecule.therapies.for.cancer,.
Nature
Reviews Cancer
.6.(9),.714-727,.2006.
. 49.. Baselga,. J.,. Targeting. the. epidermal. growth. factor. receptor. with. tyrosine. kinase. inhibitors:.
small.molecules,.big.hopes,.
Journal of Clinical Oncology
20.(9),.2217-2219,.2002.
. 50.. Spivakkroizman,.T.,.Rotin,.D.,.Pinchasi,.D.,.Ullrich,.A.,.Schlessinger,.J.,.and.Lax,.I.,.Hetero-
dimerization. of. C-ERBB2. with. different. epidermal. growth-factor. receptor. mutants. elic-
its. stimulatory. or. inhibitory. responses,.
Journal of Biological Chemistry
. 267. (12),. 8056-8063,.
1992.
. 51.. Olayioye,.M..A.,.Update.on.HER-2.as.a.target.for.cancer.therapy—intracellular.signaling.path-
ways.of.ErbB2/HER-2.and.family.members,.
Breast Cancer Research
.3.(6),.385-389,.2001.
. 52.. Tanner,.M.,.Jarvinen,.P.,.and.Isola,.J.,.Ampliication.of.HER-2/neu.and.topoisomerase.II.alpha.
in.primary.and.metastatic.breast.cancer,.
Cancer Research
.61.(14),.5345-5348,.2001.
. 53.. Nahta,. R.,. and. Esteva,. F.. J.,. HER-2-targeted. therapy:. lessons. learned. and. future. directions,.
Clinical Cancer Research
.9.(14),.5078-5084,.2003.
. 54.. Esteva,.F..J.,.Valero,.V.,.Booser,.D.,.Guerra,.L..T.,.Murray,.J..L.,.Pusztai,.L.,.Cristofanilli,.M.,.Arun,.
B.,.Esmaeli,.B.,.Fritsche,.H..A.,.Sneige,.N.,.Smith,.T..L.,.and.Hortobagyi,.G..N.,.Phase.II.study.of.
weekly.docetaxel.and.trastuzumab.for.patients.with.HER-2-overexpressing.metastatic.breast.
cancer,.
Journal of Clinical Oncology
.20.(7),.1800-1808,.2002.
. 55.. Persons,.D..L.,.Bui,.M..M.,.Lowery,.M..C.,.Mark,.H..F..L.,.Yung,.J..F.,.Birkmeier,.J..M.,.Wong,.
E.. Y.,. Yang,. S.. J.,. and. Masood,. S.,. Fluorescence.
in situ
. hybridization. (FISH). for. detection. of.
HER-2/neu.ampliication.in.breast.cancer:.a.multicenter.portability.study,.
Annals of Clinical and
Laboratory Science
30.(1),.41-48,.2000.
. 56.. Fornier,. M.,. Risio,. M.,. Van. Poznak,. C.,. and. Seidman,.A.,. HER2. testing. and. correlation. with.
eficacy.of.trastuzumab.therapy,.
Oncology—New York
.16.(10),.1340,.2002.
. 57.. Vogel,.C..L.,.Cobleigh,.M..A.,.Tripathy,.D.,.Gutheil,.J..C.,.Harris,.L..N.,.Fehrenbacher,.L.,.Slamon,.
D..J.,.Murphy,.M.,.Novotny,.W..F.,.Burchmore,.M.,.Shak,.S.,.Stewart,.S..J.,.and.Press,.M.,.Eficacy.
and.safety.of.trastuzumab.as.a.single.agent.in.irst-line.treatment.of.HER2-overexpressing.met-
astatic.breast.cancer,.
Journal of Clinical Oncology
.20.(3),.719-726,.2002.
. 58.. Nahta,.R.,.Takahashi,.T.,.Ueno,.N..T.,.Hung,.M..C.,.and.Esteva,.F..J.,.P27(kip1).down-regulation.is.
associated.with.trastuzumab.resistance.in.breast.cancer.cells,.
Cancer Research
.64.(11),.3981-3986,.
2004.
. 59.. Nagata,.Y.,.Lan,.K..H.,.Zhou,.X..Y.,.Tan,.M.,.Esteva,.F..J.,.Sahin,.A..A.,.Klos,.K..S.,.Li,.P.,.Monia,.
B..P.,.Nguyen,.N..T.,.Hortobagyi,.G..N.,.Hung,.M..C.,.and.Yu,.D..H.,.PTEN.activation.contrib-
utes.to.tumor.inhibition.by.trastuzumab,.and.loss.of.PTEN.predicts.trastuzumab.resistance.in.
patients,.
Cancer Cell
.6.(2),.117-127,.2004.
. 60.. Lewis,. G.. D.,. Figari,. I.,. Fendly,. B.,. Wong,. W.. L.,. Carter,. P.,. Gorman,. C.,. and. Shepard,. H.. M.,.
Differential. responses. of. human. tumor-cell. lines. to. anti-P185(HER2). monoclonal-antibodies,.
Cancer Immunology Immunotherapy
.37.(4),.255-263,.1993.
. 61.. Cooley,.S.,.Burns,.L..J.,.Repka,.T.,.and.Miller,.J..S.,.Natural.killer.cell.cytotoxicity.of.breast.cancer.
targets. is. enhanced. by. two. distinct. mechanisms. of. antibody-dependent. cellular. cytotoxicity.
against.LFA-3.and.HER2/neu,.
Experimental Hematology
.27.(10),.1533-1541,.1999.
. 62.. Clynes,.R..A.,.Towers,.T..L.,.Presta,.L..G.,.and.Ravetch,.J..V.,.Inhibitory.Fc.receptors.modulate.
in vivo
.cytoxicity.against.tumor.targets,.
Nature Medicine
6(4),.443-446,.2000.
. 63.. Laughner,.E.,.Taghavi,.P.,.Chiles,.K.,.Mahon,.P..C.,.and.Semenza,.G..L.,.HER2.(neu).signaling.
increases. the. rate. of. hypoxia-inducible. factor. 1. alpha. (HIF-1. alpha). synthesis:. novel. mecha-
nism.for.HIF-1-mediated.vascular.endothelial.growth.factor.expression,.
Molecular and Cellular
Biology
.21.(12),.3995-4004,.2001.
. 64.. Izumi,.Y.,.Xu,.L.,.di.Tomaso,.E.,.Fukumura,.D.,.and.Jain,.R..K.,.Tumor.biology—Herceptin.acts.
as.an.anti-angiogenic.cocktail,.
Nature
.416.(6878),.279-280,.2002.
