Biomedical Engineering Reference
In-Depth Information
4.7 Conclusion
Theragnostic.nanoparticles.are.a.new.class.of.agents.that.offer.the.ability.to.diagnose.and.
characterize.disease.in.early.stages,.to.deliver.therapy.speciic.for.that.disease.phenotype,.
and. to. monitor. serially. the. response. to. that. therapy.. The. ability. to. characterize. disease.
quantitatively.through.speciic.biomarkers.(like.HER2.or.angiogenesis).can.help.stratify.
patients.by.their.predicted.response.to.different.therapy.options..Targeted.nanoparticles,.
which.not.only.safely.and.stealthily.carry.highly.potent.therapeutics,.but.also.are.visible.
via.noninvasive.clinical.imaging,.can.offer.conirmation.of.drug.dosing.with.a.prediction.
of.response.at.the.time.of.dosing..The.actual.response,.beginning.only.days.posttherapy,.
may. be. monitored. serially. employing. the. same. particles. used. to. diagnose,. thus. either.
conirming. effect.or. suggesting.an.alteration. sooner. rather. than. later.. All. these. features.
coalesce.to.help.usher.in.the.possibility.of.personalized.medicine.
References
. 1.. Service,. R.F.. Molecular. Imaging:. new. probes. open. windows. on. gene. expression,. and. more..
Science
.280,.1010-1011.(1998).
. 2.. Weissleder,.R..Molecular.imaging:.exploring.the.next.frontier..
Radiology
.212,.609-614.(1999).
. 3.. Pettigrew,.R.I.,.Fee,.C.A.,.and.Li,.K.C..Changes.in.the.world.of.biomedical.research.are.moving.
the.ield.of.“personalized.medicine”.from.concept.to.reality..
J Nucl Med
.45,.1427.(2004).
. 4.. Weissleder,.R.,.and.Mahmood,.U..Molecular.imaging..
Radiology
.219,.316-333.(2001).
. 5.. O'Reilly,. R.K.,. Hawker,. C.J.,. and. Wooley,. K.L.. Cross-linked. block. copolymer. micelles:. func-
tional.nanostructures.of.great.potential.and.versatility..
Chem Soc Rev
.35,.1068-1083.(2006).
. 6.. Weber,.W.A.,.Czernin,.J.,.Phelps,.M.E.,.and.Herschman,.H.R..Technology.insight:.novel.imag-
ing.of.molecular.targets.is.an.emerging.area.crucial.to.the.development.of.targeted.drugs..
Nat
Clin Pract Oncol
.5,.44-54.(2008).
. 7.. Tran,.T.D.
,
et.al..Clinical.applications.of.perluorocarbon.nanoparticles.for.molecular.imaging.
and.targeted.therapeutics..
Int J Nanomed
.2,.515-526.(2007).
. 8.. Tomalia,. D.A.,. Reyna,. L.A.,. and. Svenson,. S.. Dendrimers. as. multi-purpose. nanodevices. for.
oncology.drug.delivery.and.diagnostic.imaging..
Biochem Soc Trans
.35,.61-67.(2007).
. 9.. Michalet,. X.
,
et. al.. Quantum. dots. for. live. cells,.
in vivo
. imaging,. and. diagnostics..
Science
. 307,.
538-544.(2005).
. 10.. Kaneda,.M.M.,.Caruthers,.S.,.Lanza,.G.M.,.and.Wickline,.S.A..Perluorocarbon.nanoemulsions.
for.quantitative.molecular.imaging.and.targeted.therapeutics..
Ann Biomed Eng
.37,.1922-1933.
(2009).
. 11.. Shokeen,.M.,.Fettig,.N.M.,.and.Rossin,.R..Synthesis,.
in vitro
.and.
in vivo
.evaluation.of.radiola-
beled.nanoparticles..
Q J Nucl Med Mol Imaging
52,.267-277.(2008).
. 12.. Surendiran,.A.,.Sandhiya,.S.,.Pradhan,.S.C.,.and.Adithan,.C..Novel.applications.of.nanotech-
nology.in.medicine..
Indian J Med Res
.130,.689-701.(2009).
. 13.. Junghanns,.J.U.,.and.Muller,.R.H..Nanocrystal.technology,.drug.delivery.and.clinical.applica-
tions..
Int J Nanomed
.3,.295-309.(2008).
. 14.. Wickline,.S.A.,.Neubauer,.A.M.,.Winter,.P.,.Caruthers,.S.,.and.Lanza,.G..Applications.of.nano-
technology.to.atherosclerosis,.thrombosis,.and.vascular.biology..
Arterioscler Thromb Vasc Biol
.26,.
435-441.(2006).
