Biomedical Engineering Reference
In-Depth Information
α ν β 3 -Fumagillin
α ν β 3 -No Drug
50
Treatment
10
1 Wk Post
(a)
25
Treatment
20
1 Week Post
15
10
*
5
0
Targeted, with Drug
Targeted, no Drug
(b)
FIGURE 4.4
Targeted.drug.delivery.with.image-based.monitoring.of.response..Using.an.α ν β 3 -targeted.nanoparticle.to.high-
light.with.MRI.angiogenesis.in.these.atherosclerotic.aortas,.we.can.see.signiicant.enhancement.at.baseline.(a,.
top.row)..When.imaged.a.week.later.(second.row).using.the.angiogenesis-targeted.nanoparticles,.the.subject.
receiving. fumagillin. via. targeted. theragnostic. nanoparticles. shows. marked. reduction. in.signal,.whereas. the.
control.subject,.having.received.no.drug,.shows.a.similar.amount.of.angiogenesis..Averaging.across.all.subjects.
(b,.lines.indicate.individual.subjects),.we.see.a.signiicant.reduction.of.atherosclerotic-related.angiogenesis.in.
those.receiving.theragnostic.particles,.whereas.those.receiving.imaging-only.nanoparticles.(no.drug).showed.
no.change.in.disease.level..(Reprinted.with.permission.from.Winter,.P.M. , et.al.,. Arterioscler Thromb Vasc Biol ,.
26,.2103-2109,.2006.)
4.6 MonitoringResponsetoTherapy
Just. as. the. diagnostic. nanoparticles. can. be. used. to. detect. and. characterize. markers. of.
disease,.so.they.can.be.used.to.evaluate.the.change.in.these.markers.as.a.result.of.therapy..
This.can.be.true.as.a.method.to.appraise.the.effects.of.traditional.drugs,.or.as.in.the.exam-
ples.previously.cited,.it.can.be.to.monitor.the.response.to.nanoparticle-delivered.therapy..
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