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compounds showed a dose-dependent inhibitory effect on yeast a -glucosi-
dase. They exhibited a significant degree of inhibition with IC 50 values of
5.3 and 11.1 m M. Kinetic analysis of the inhibitors elucidated typical pro-
gress curves for noncompetitive inhibition. Pongamol (
42
) and ovalitenone
(
) were isolated from the root extract of Derris indica ( Rao et al., 2009 ) .
Compound
43
showed potent inhibition activity on rat intestinal
a -glucosidase with an IC 50 value of 103.5 m M. Nevertheless, 3 0 ,4 0 -
methylenedioxy moiety (
42
43
) in chalcone decreased enzyme inhibitory
potential.
2.5. Polyacetylenes (Fig. 3.6)
Four polyacetylenes, panaxjapyne A (
44
), panaxjapyne C (
45
), (3 R )-(
)-
falcarinol (
) from the ethanol extract of
the roots of Panax japonicus were found to have a -glucosidase from baker's
yeast inhibition activity with IC 50 values of 71.82, 175.42, 67.78, and
22.21 m M, respectively ( Chan et al., 2010 ) . Moreover,
46
), and (3 S ,10 S )-panaxydiol (
47
44
gave more potent
inhibition values than
, indicating diols at C-9 and C-10 and the terminal
vinylic group are responsible for decreasing a -glucosidase inhibitory activ-
ity. (10 S ,15 R , Z )-10,15-dihydroxyheptadeca-8,16-dien-11,13-diynyl ace-
tate (
45
) were isolated from A. keiskei ( Luo et al.,
2012 ). They exhibited potent inhibition activity on yeast maltase with
IC 50 values of 53.26 and 19.13 m M, respectively.
48
49
) and falcarindiol (
Figure 3.6 Chemical structures for polyacetylenes, compounds 44-49.
 
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