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compounds showed a dose-dependent inhibitory effect on yeast
a
-glucosi-
dase. They exhibited a significant degree of inhibition with IC
50
values of
5.3 and 11.1
m
M. Kinetic analysis of the inhibitors elucidated typical pro-
gress curves for noncompetitive inhibition. Pongamol (
42
) and ovalitenone
(
Compound
43
showed potent inhibition activity on rat intestinal
a
-glucosidase with an IC
50
value of 103.5
m
M. Nevertheless, 3
0
,4
0
-
methylenedioxy moiety (
42
43
) in chalcone decreased enzyme inhibitory
potential.
2.5. Polyacetylenes
(Fig. 3.6)
Four polyacetylenes, panaxjapyne A (
44
), panaxjapyne C (
45
), (3
R
)-(
)-
falcarinol (
) from the ethanol extract of
the roots of
Panax japonicus
were found to have
a
-glucosidase from baker's
yeast inhibition activity with IC
50
values of 71.82, 175.42, 67.78, and
46
), and (3
S
,10
S
)-panaxydiol (
47
44
gave more potent
inhibition values than
, indicating diols at C-9 and C-10 and the terminal
vinylic group are responsible for decreasing
a
-glucosidase inhibitory activ-
ity. (10
S
,15
R
,
Z
)-10,15-dihydroxyheptadeca-8,16-dien-11,13-diynyl ace-
tate (
45
2012
). They exhibited potent inhibition activity on yeast maltase with
IC
50
values of 53.26 and 19.13
m
M, respectively.
48
49
) and falcarindiol (
Figure 3.6 Chemical structures for polyacetylenes, compounds 44-49.