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29
showed potent inhibition activity on a -glucosidase. The IC 50 value of
was 9.7 m M( Chang & Kang, 2012 ) .
The ethyl acetate extract from the leaves of Lagerstroemia speciosa inhibited
yeast a -glucosidase activity with an IC 50 value of 88.72 m g/mL ( Hou et al.,
2009 ). Six pentacyclic triterpenes were isolated from L. speciosa , and they
exhibited different inhibition activity against yeast a -glucosidase while they
showed no or weak inhibition activity on porcine pancreatic a -amylase.
Arjunolic acid (
) showed weak inhibition activity
on a -glucosidase with IC 50 values of 38.1 and 61.4 m M, respectively.
Oleanolic acid (
30
) and Asiatic acid (
31
)
showed moderate a -glucosidase inhibitory activities with the IC 50 values
of 13.8, 11.7, and 17.2 m M, respectively. Corosolic acid (
32
), maslinic acid (
33
), and 23-hydroxyursolic acid (
34
35
) showed the
highest inhibition activity against a -glucosidase with an IC 50 value of
7.5 m M in an uncompetitive manner. The ethanol extract of the leaves of
Fagus hayatae was found to be active in the inhibition of bacteria
a -glucosidase ( Lai et al., 2012 ) . 2,3- seco -20(29)-Lupene-2,3-dioic acid
(
) was isolated from F. hayatae and showed inhibition activity on the
a -glucosidase with an IC 50 value of 62.1 m M.
36
2.4. Chalcones (Fig. 3.5)
Three chalcones, isobavachalcone (
37
), xanthoangelol (
38
), and 4-hydroxy-
derricin (
), isolated from the aerial parts of tomorrow's leaf, Angelica
keiskei , showed potent inhibition activity on maltase from yeast with IC 50
values of 20.32, 11.54, and 33.76 m M, respectively ( Luo et al., 2012 ).
Two chalcones, broussochalcone A (
39
) were
isolated from the roots of B. papyrifera ( Ryu et al., 2010 ) . These two
40
) and broussochalcone B (
41
Figure 3.5 Chemical structures for chalcones, compounds 37-43.
 
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