Biology Reference
In-Depth Information
Table 3.1 A summary of newly identified
a
-glucosidase and
a
-amylase inhibitors from natural plants
Inhibition
mechanism
No.
Plant
Part used
Inhibitor
Enzyme origin
Method
IC
50
Reference
a
-Glucosidase inhibitors
Polyphenols
Flavonoids
1
Vigna
angularis
-
Vitexin
Rat intestine
pNPG
926
m
M-
2
Isovitexin
Rat intestine
pNPG
11 mM
-
3
Tinospora
cordifolia
Leave
Saponarin
Fungal maltase
(
Aspergillus niger
,
M-125)
Glucose oxidase/
peroxidase
55
m
M
Mixed
Invertase
(Baker's yeast)
Glucose oxidase/
peroxidase
48
m
M
Mixed
Maltase/sucrase
(Rat intestine)
Glucose oxidase/
peroxidase
48/35
m
M Mixed
4
Kaempferia
parviflora
Rhizome
5,7,3
0
,4
0
-
Tetramethoxyflavone
Rat intestine
4-Methylum-belliferyl
a
-
D
-glucopyranoside
20.4
m
M-
5
5,7,4
0
-
Trimethoxyflavone
Rat intestine
4-Methylum-belliferyl
a
-
D
-glucopyranoside
54.3
M-
m
3,5,7,3
0
,4
0
-
Pentamethoxyflavone
6
Rat intestine
4-Methylum-belliferyl
a
-
D
-glucopyranoside
64.3
m
M-
