Biomedical Engineering Reference
In-Depth Information
III
Physical Aspects of
Emerging Technology
for Thermal Therapy
12
Evolving Tools for Navigated Image-Guided Thermal Cancer Therapy
Kevin Cleary, Emmanuel Wilson,
and Filip Banovac
......................................................................................................................................................................... 203
Introduction
•
Technology of Navigation Systems
•
Clinical Applications
•
Potential Future Developments
•
Summary
13
Temperature Imaging Using Ultrasound
R. Martin Arthur
........................................................................................... 219
Introduction
•
Thermal Effects on Backscattered Ultrasound
•
Image Motion
•
Ultrasonic Measurement of
Temperature
•
Discussion
•
Summary and Conclusions
14
Focused Ultrasound Applications for Brain Cancer
Meaghan A. O'Reilly and Kullervo Hynynen
......................... 241
Introduction
•
Focused Ultrasound in the Brain
•
Therapeutic Effects of Ultrasound on the Brain
•
Applications and
Clinical Studies
•
Potential Future Treatments
•
Needs for Advancement of Transcranial FUS into Routine Clinical
Practice
15
Extracorporeal Ultrasound-Guided High-Intensity Focused Ultrasound Ablation for
Cancer Patients
Feng Wu
...................................................................................................................................................... 255
Clinical History of High-Intensity Focused Ultrasound Tumor Ablation
•
Physical Principles of HIFU
Ablation
•
Biological Effects of Thermal Ablation on Tumor
•
HIFU Therapeutic Plan
•
HIFU 3-D Conformal
herapy
•
Medical Imaging in HIFU Ablation
•
Clinical Applications of Extracorporeal US-Guided HIFU for Solid
Malignancies
•
Conclusions
16
Using Hyperthermia to Augment Drug Delivery
Mark W. Dewhirst
........................................................................... 279
Introduction
•
Mild Hyperthermia Is Ideal for Augmenting Drug Delivery and Efficacy in Tumors
•
Fundamental
Limitations for Effective Drug Delivery and Antitumor Activity
•
Effects of Hyperthermia on Liposome Uptake in
Tissues
•
Development of Thermally Sensitive Liposomes
•
Factors That Influence Effectiveness of LTSL-Dox When
Combined with Hyperthermia
•
Use of Imaging to Quantify Drug Delivery from LTSL-Dox and Establishment of
Treatment Optimization Strategies
•
Clinical Applications of LTSL-Dox
•
Future Directions
17
Magnetic Nanoparticles for Cancer Therapy
Andreas Jordan, Michael L. Etheridge, and John C. Bischof
............. 293
Introduction
•
Scientific Background
•
Synthesis and Modification of Iron Oxide Nanoparticles
•
Biological
Effects
•
Clinical Application in Cancer Therapy
•
What Comes Next?
18
Application of Gold Nanoparticles (GNP) in Laser Thermal Therapy
Zhenpeng Qin and John C. Bischof
.......... 319
Introduction
•
Overview of Laser-Tissue Interactions
•
Laser Fluence Estimation in Tissues
•
Optical Properties of
GNPs
•
Laser GNP Effects I—Thermal Response at Multiple Scales
•
Laser GNP Effects II—Physical and Biological
Responses at Multiple Scales
•
Clinical Studies
•
Conclusion and Future Studies
19
Thermochemical Ablation
Erik N. K. Cressman
................................................................................................................ 339
Practical Considerations
•
Future Directions
201
