Biomedical Engineering Reference
In-Depth Information
cell diameter from 10 to 40 mm. The transducer (phased array)
has a focal length of 140 mm and employs 256 elements operat-
ing at frequencies between 1.2 and 1.5 MHz. Another impor-
tant feature of the Sonalleve system is its automatic temperature
feedback control system, which modulates power to the acoustic
sources while the focus is being scanned based on MR-measured
temperature feedback (Enholm et al. 2010). Experiments have
shown that under- and overtreatment can be prevented with
this control system. Moreover, a recently completed multicenter
prospective clinical trial showed that volumetric MR-HIFU is
safe and feasible in the treatment of uterine fibroids (Voogt et al.
2012). Finally, this system is also being used by investigators to
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