Biology Reference
In-Depth Information
Chapter 6
Stimulation of Wound Revascularization
by Adenosine Receptor Activation
M. Carmen Montesinos and María D. Valls
Abstract Adenosine is an endogenous mediator implicated in wound healing.
The exact mechanisms and receptors involved are still under evaluation. We have
observed that topical application of a selective adenosine A 2A receptor agonist pro-
motes wound healing in experimental animals, both healthy and with impaired
healing. Histological analysis revealed that adenosine promoted granulation tis-
sue formation, with increased cellularity, matrix deposition, and vessel density.
Adenosine may exert effects on many different cell types that finally result in pro-
motion of angiogenesis and, furthermore, homing of endothelial precursor cells
into sites of injury. We will review the effect of adenosine receptor activation on
microvascular endothelial cell function and on wound revascularization.
Keywords Adenosine receptors
·
Wound healing
·
Angiogenesis
·
Vasculogenesis
cell migration
·
Cell
proliferation
·
Dermal microvascular
endothe-
lial cell
·
Endothelial precursor cells
·
Inflammation
·
Cytokines
·
Hypoxia
·
Hypoxia-
inducible factor (HIF)
·
Vascular endothelial growth factor
·
Thrombospondin-1
·
Murine
air pouch model
·
Bone marrow transplantation
·
Fibrinolytic
system
·
Plasminogen activation
·
Extracellular matrix
·
Annexin II
6.1 Introduction
Wound healing is a dynamic and complex process that involves a well coordi-
nated, highly regulated series of events including inflammation, tissue formation,
revascularization and tissue remodeling [13]. However, this orderly progression of
B
M.C. Montesinos (
)
Department de Farmacologia, Universitat de València, Ave. Vicent Andrès Estellès s/n, 46100
Burjassot Valencia, Spain
Instituto de Reconocimiento Molecular y Desarrollo Tecnológico, Centro Mixto Universidad
Politécnica de Valencia, Universidad de Valencia, Spain
Department of Medicine, New York University School of Medicine, 550 First Ave, New York, NY
10016, USA
e-mail: m.carmen.montesinos@uv.es
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