Biomedical Engineering Reference
In-Depth Information
(a)
100 µm
(b)
30
õ
õ
õ
õ
õ
õ
õ
20
õ
õ
õ
10
õ
Active
DRT
¤
Ungrafted
control
0
0.1 1 10 100 1000
Average pore diameter (µm)
14.2
(a) A scaffold with high biological activity: Dermis regeneration
template (DRT). Based on a graft copolymer of type I collagen and
chondroitin 6-sulfate. Pore volume fraction 99.5%. Average pore
diameter 80 µm. (b) Contraction blocking activity of a homologous
series of scaffolds increases with magnitude of vertical coordinate.
Sharp differences in contraction blocking activity owing to differences
in pore size alone are observed (Yannas
et al
.,1989).
regeneration in the presence of a DRT, MFB comprise only about 10% of the total
number of fibroblasts; in contrast, in the absence of a DRT, MFB comprise 50% of
total number of fibroblasts (Murphy
et al
., 1990). The observed reduction in the
number of MFB probably results, at least in part, from a built-in feature in the DRT
structure, the known absence of collagen fiber banding (without loss of triple
