Biology Reference
In-Depth Information
B. perfoliata
and
B. scordioides
contain
linarin and verbascoside (Fig. 17.1) (Avila,
2002; Avila
et al
., 2005). Linarin is a flavo-
noid (acacetin-7-O-beta-d-rutinoside); it
showed a selective dose-dependent inhibi-
tory effect on acetylcholinesterase (Oinonen
et al
., 2006). Linarin is also reported to induce
apoptosis in human prostate cancer cells,
which was also accompanied by poly (ADP-
ribose) polymerase (PARP) cleavage (Singh
et al
., 2005), has sedative and sleep-enhancing
properties in mice (Fernández
et al
., 2004),
and activate macrophages and modulate
cytokine production (Han
et al
., 2002). It also
possesses anti-inflammatory, analgaesic, dia-
phoretic, hypotensive, anti-stress/anxiety,
antipyretic (Martínez-Vázquez
et al
., 1998) and
amoebicidal activities (Rodríguez-Zaragoza
et al
., 1999). We isolated and also prepared
linarin peracetate to evaluate the photopro-
tective properties. Verbascoside or acteoside
is an active phenylpropanoid glycoside. This
compound is structurally characterized by
caffeic acid and 4,5-hydroxyphenylethanol
bound to a b-(
d
)-glucopyranoside, found in
bitter tea and many medicinal plants, has
exhibited a wide biological activity, free-radical
scavenging being the most representative
one. It is a powerful antioxidant either by
direct scavenging of reactive oxygen and
nitrogen species or by acting as chain-breaking
peroxyl radical scavenger (Korkina, 2007;
Perron and Brumaghim, 2009). Moreover,
anti-tumour, antimicrobial (Avila
et al
., 1999),
anti-inflammatory (Speranza
et al
., 2010),
analgaesic, antipyretic (Wahba
et al
., 2010),
anti-thrombotic and wound healing (Korkina
et al.,
2007), and chemopreventive (Hwang
et al
., 2010) properties have been previously
described.
17.4 Natural Products Isolated
from
Yucca periculosa
The genus
Yucca
has about 35 to 40 species,
which makes it the second largest genus of
RO
O
O
OR
RO
RO
O
O
OR
O
RO
RO
O
RO
Linarin: R = H; Linarin acetate: R = Ac
OH
HO
CH
2
CH
2
O
O
OH
HO
H
O
HO
C
C
CO
HO
O
O
OH
H
Verbascoside
OH
OH
Fig. 17.1.
Structures of UVB-absorbing compounds isolated from
Buddleja perfoliata
and
Buddleja
scordioides
.
Search WWH ::
Custom Search