Chemistry Reference
In-Depth Information
is also prescribed for persistent pain. Venlafaxine hydrochloride (Effexor ® ,
Pfizer) is also a dual reuptake inhibitor of serotonin and norepinephrine. Ven-
lafaxine has a chiral carbon and is administered as a racemic mixture.
CH 3
CH 3
N
OH
S
CH 3 HCl
Duloxetine hydrochloride
HCl
H
H 3 C
O
Venlafaxine hydrochloride
REFERENCES
1. Louis Quin, John Tyrell. Fundamentals of Heterocyclic Chemistry .NewYork:
Wiley; 2010:196.
2. D Johnson, J Li, editors. The Art of Drug Synthesis . New York: Wiley; 2007.
3. J Li, D Johnson, D Sliskovic, B Roth. Contemporary Drug Synthesis .NewYork:
Wiley; 2004.
4. J Saunders. Top Drugs , Top Synthetic Routes. Oxford University Press; 2000.
5. T Lemke, et al., editors. Foye's Principles of Medicinal Chemistry . 7th ed.
Lippincott, Baltimore, MD; 2013:1031.
6. Abbott 2011 Annual Report, Abbott Laboratories, Abbott Park, IL.
7. N Singh, et al. Mini-Reviews in Medicinal Chemistry 2009; 9:1272 - 1283.
8. V Roger, et al. Circulation 2012; 125:e2 - e220.
9. E Istvan, J Deisenhofer. Biochimica et Biophysica Acta 2000; 1529:9 - 18.
10. E Istvan. Atherosclerosis Supplements 2003; 4:3 - 8.
11. Irina Buhaescu, Hassane Izzedine. Clinical Biochemistry 2007; 40:575 - 584.
12. N. Singh, et al. Mini-Reviews in Medicinal Chemistry 2009; 9:1272 - 1283.
13. John LaMattina. Drug Truths . New York: Wiley; 2009:15.
14. AstraZeneca Annual Report and Form 20-F Information 2011.
15. R Monaghan, et al. U.S. Pat. No. 4,231,938. 1980.
16. W Hoffman, R Smith, A Willard. U.S. Pat. No. 4,444,784. 1984.
17. VA O'Neill, KL Evenstad. U.S. Pat. No. 5,268,181. 1993.
18. D Johnson, J Li, editors. The Art of Drug Synthesis . New York: Wiley; 2007:187.
19. Sherry L Murphy, Jiaquan Xu, Kenneth D Kochanek. National Vital Statistics
Reports January 11, 2012; 60(4).
20. V Roger, et al. Circulation 2012; 125:e2 - e220.
21. V Roger, et al. Circulation 2012; 125:e2 - e220.
22. T Lemke, et al., editors. Foye's Principles of Medicinal Chemistry . 7th ed.
Lippincott, Baltimore, MD; 2013:784.
23. D Carini, J Duncia, P Wong. U.S. Pat. No. 5,138,069. 1992.
24. D Johnson, J Li, editors. The Art of Drug Synthesis . New York: Wiley; 2007:132.
 
 
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