Biomedical Engineering Reference
In-Depth Information
The systems using stirrers can have the stirring element either driven mag-
netically or connected through a sealed shaft. Oscillating types mix by mov-
ing the liquid inside a bag (mostly 2D types) by rocking them or shaking
using mechanical vibrations or ultrasonic vibrations. Generally, the mixing
systems that do not involve any mechanical parts inside the bag (either 2D or
3D) are preferred to reduce the cost, the risk of damage to the bag from rotat-
ing devices, the grinding of bag, or the stirrer inside the bag; those stirring
systems that use a magnetic field provide better sterility compared to those
that are magnetically coupled.
Stirring Magnetic Mixer
• XDM (Xcellerex), 100 L to 1,000 L, the XDM Quad Mixing System
comprises an integrated magnetic stirrer with a compact motor, a
bottom-mounted disposable stirrer; the coupling between the motor
and the disposable stirrer is magnetic. The square configuration
offers enhanced mixing efficiency through a natural baffling effect
and compact storage capability. The bottom is slanted to ensure a
low residual volume after discharge.
• The Flexel 3D LevMix System for Palletank, 50 L to 1,000 L, combines
the LevTech levitated impeller licensed by ATMI and the Sartorius-
Stedim Flexel 3D Bag. It comprises a stainless steel, cube-shaped
container with a door for ease of bag mounting. In addition, it has
windows to enable observation of the mixing process, a drive unit
for levitating or rotating the stirrer, and a disposable bag with a cen-
ter-mounted magnetic stirrer.
• Magnetic Mixer (ATMI Life Sciences), 30 L to 2,000 L.
• Jet-Drive (ATMI Life Sciences), 50 L to 200 L.
• Mobius (Millipore), 100 L to 500 L.
• LevMixer (ATMI Life Sciences), 30 L to 2,000 L, is ultraclean as it
does not produce any residue from mechanical motion, suitable for
downstream operations as well.
Stirring Mechanical Coupling Mixer
• S.U.M. (Thermo Fisher Scientific), 50 L to 2,000 L; there are two types
of magnetic stirrers driven by a stirring plate available for different
