Biomedical Engineering Reference
In-Depth Information
Solutions target key steps in the monoclonal antibody (mAb) processing/
purification train, designed and optimized for
• Clarification
• Media and buffer preparation
• Tangential flow filtration (TFF)
• Virus filtration
GE Lifesciences ( www.gelifesciences.com ) offer a ReadyToProcess system to
include all steps of upstream and downstream processing. These compo-
nents include
1. Bioreactors
The Wave Bioreactor is a scalable, effective, cost-efficient rocking
platform for cell culture. The culture medium and cells contact
only a presterile, disposable Cellbag ensuring very short setup
times. There is no need for cleaning or sterilization, providing
easy operation and protection against contamination. The rock-
ing motion of the platform induces waves in the culture fluid to
provide efficient mixing and gas transfer, resulting in an envi-
ronment well-suited for cell growth. The Wave system is com-
pletely scaleable across our platform ranging from 200 mL to
500 L.
2. Disposable bioreactor bags
Manufactured from multilayered laminated clear plastic, Cellbag
disposable bioreactors are suitable for specific cell culture pro-
cess needs for research, development, or cGMP manufacturing
operations. Cellbag components are similar to those used for
biological storage bags and meet USP Class VI specifications for
plastics. Validation data and Cellbag DMF are available to dem-
onstrate biocompatibility. Cellbags can be highly customized to
meet specific processing requirements.
3. Fluid Management
ReadyCircuit assemblies comprise bags, tubing, and connec-
tors. Together with ReadyToProcess filters and sensors,
ReadyCircuit assemblies form self-contained bioprocessing
modules that maintain an aseptic path and provide conve-
nience by removing time-consuming process steps associated
with conventional systems. Bags, tube sets, filters, and related
equipment can be secured in appropriate orientations for effi-
cient operation using the ReadyKart mobile processing sta-
tion. With an array of features, and optional accessories, the
Search WWH ::




Custom Search