Biomedical Engineering Reference
In-Depth Information
BioOptimal MF-SL™
Designed specifically for use in cell culture clarification applications,
BioOptimal MF-SL filters enable biopharmaceutical manufacturers to
improve the efficiency and effectiveness of their protein harvest step.
TechniKrom™
Asahi Kasei Bioprocess, Inc., provides technologically advanced bioprocess
equipment, products, and services to the biopharmaceutical, pharmaceutical,
veterinary, and nutraceutical industries that permit the lowest cost of pro-
duction and highest innate product quality, especially in cGMP-regulated
environments. We help our clients implement true manufacturing science in
their facilities to enable their achievement of these goals.
GE Healthcare
Process scale hollow fiber cartridges offered by GE Healthcare are provided
in eight basic configurations covering a membrane area range of 0.92 to 28 m²
(9.9 to 300 ft²) depending on the fiber internal diameter.
Spectrum
Spectrum disposable CellFlo hollow fiber membranes are specially designed
for the gentle and efficient separation of whole cells in microfiltration, bio-
reactor perfusion, and culture harvest applications. Very similar to GE's
circulatory system, CellFlo combines the advantages of tangential flow
microfiltration (0.2 µm and 0.5 µm pores sizes) with larger hollow fiber flow
channels (1 mm ID) to provide gentler efficacious microseparations without
the risk of cell lysis. Other cell separation technologies have a higher risk
of lysis resulting in ruptured cells and culture harvests contaminated with
intracellular macromolecules. Perfectly suited for continuous cell perfusion
and bacterial fermentation, CellFlo membranes isolate secreted proteins
while eliminating spent media containing metabolic wastes and drawing
in fresh nutrient-rich media. Consequently, CellFlo enables cultures to grow
to a higher cell density with higher viability providing as much as a tenfold
increase of daily production of secreted proteins.
Whether performing a cell perfusion or conducting a simple microfiltra-
tion, disposable CellFlo modules can either be autoclaved or purchased irra-
diated (irr) for quick sterile assembly. Spectrum offers disposable CellFlo
membrane modules in the full range of MiniKros and KrosFlo sizes and sur-
face areas for processing volumes ranging from 500 mL to 1,000 L. All CellFlo
membranes have a 1 mm fiber inner diameter, available in 0.2 µm and 0.5 µm
pore sizes. Also to be considered are the MaxCell, Spectrum Laboratories
CellFlo
®
, and KrosFlo
®
module families.
