Biomedical Engineering Reference
In-Depth Information
50 Micrometer
FIGURE 8.2
Sartobind Q membrane and a standard chromatographic matrix.
cross-linked cellulose network. Diffusion time in adsorbers is negligible
because of the large pores and immediate binding of the target substance
to the ligands. There is no pore diffusion as given in conventional beads
but film diffusion anywhere on the microporous membrane structure
(Figure 8.3). At convective flow conditions, the movement of the molecules of
the mobile phase is directed by pump pressure only. That is why membrane
adsorbers feature extremely short cycle times and exceptionally high flow
rate and throughput.
There are several available ligands, including
Conventional bead
Membrane Adsorber
Convective flow
Pore diffusion
Film diffusion
FIGURE 8.3
Existing transport phenomena in conventional beads and membrane adsorbers.
