Biomedical Engineering Reference
In-Depth Information
• Daisy-chaining smaller reactors to form a larger batch that complied
with CFR 21 requirements eliminated the need to qualify several
batch sizes.
• Use of generic bags of all types because of the open structure of
the bioreactor.
• The least expensive fully validated cGMP-compliant bioreactor in
the world: cost savings on capital investment were 70%-90% com-
pared to available systems and cost savings for ongoing components
50%+. This opened up the access of bioreactors to smaller compa-
nies, research organizations, and developing countries.
Bioreactor Brand
Vendor
Maximum Size
Main Applications
Mechanically Driven/Wave-Mixed (Horizontally Oscillation)
BIOSTAT CultiBag
RM (in the past Bio
Wave)
Sartorius-Stedim
300 L CV
Cultivation of animal cells,
plant cells, and
microorganisms having
up to medium oxygen
demands: screening, seed
inoculum production,
small- and medium-
volume-scale
manufacture
Wave Bioreactor
GE Healthcare
500 L CV
Cultivation of animal cells,
seed inoculum production
AppliFlex
Applikon
25 L CV
Tsunami Bioreactor
Tsunami Bio
160 L CV per
platform
No longer available
CELL-trainer
Bioreactor, animal
Lonza
15 L CV
Cultivation of animal cells
and plant cells: screening,
seed inoculum
production, sample
production, small-
volume-scale
manufacture
CELL-trainer
Bioreactor, microbial
Cultivation of
microorganisms:
screening, seed inoculum
production, small-
volume-scale
manufacture
WUB
Nestlé
100 L CV
Cultivation of plant cells:
small- and medium-
volume-scale manufacture
Mechanically driven/
vertically Oscillation
Bay Shake
Bioreactor
Bayer Technology
Services/
Sartorius Stedim
1,000 L TV
Cultivation of animal cells:
seed inoculum
production, sample
production, small- and
medium-volume-scale
manufacture
