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0.74
vs.
0.24 mM Toluene
Phasin
Phospholipid layer
100
PHB
10
CO
∼
SCoA
PhaC
1
CH
3
CH
CH
2
CO
∼
SCoA
CO
SCoA
COO
-
∼
OH
HO
PhaB
β
-Oxidation
NADH, Fd
red
PERIPLASM
NO
3
-
NarGHI
PhaA
CH
3
CO
∼
SCoA
CH
3
C
CH
2
CO
∼
SCoA
NO
2
-
O
NO
2
-
NO
NirS
NO
NorC
N
2
O
TCA-cycle
NADH, Fd
red
NorB
CO
2
N
2
O
N
2
CYTOPLASM
NosZ
CO
2
Fig. 6. Solvent stress response of
A. aromaticum
EbN1 during anaerobic growth with semi-inhibitory concentrations of
toluene (0.74 mM). Rerouting of acetyl-CoA from TCA cycle to PHB synthesis allows keeping alkylbenzene degradation
operative under conditions of impaired denitrifi cation.
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