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Figure 5. Unrooted phylogenetic tree for the
fibrillar collagen genes showing three clades.
(from Pace et al. 2003 with permission of
Elsevier).
Figure 6. Composite of gene structures of fibrillar collagen N-propeptide and C-propeptide domains, derived
from the data of Välkkilä et al. (2001) and Pace et al. (2003) with permission of Elsevier. The very major
differences in the N-propeptide domains and N-telopeptide domains, linked to extracellular organization, in
contrast to the similar structures of the C-propeptide domains, related to intracellular molecular assembly, are
evident. The N-propeptide differences are the basis for the division into distinct clades.
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