Agriculture Reference
In-Depth Information
cancer incidence (Knekt et al., 1997). Another epidemiological study that examined the rela-
tionship between fruit and vegetable intake and the incidence of different cancers found that
for most cancers the increase in risk for people with low fruit intake in the study was about
twice as high as people with high intake (Block et al., 1992). In vitro antiproliferation stud-
ies with HepG2, human liver cancer cells, have shown phenolics from many common fruits
like cranberry, lemon, apples, and strawberries to inhibit proliferation (Sun et al., 2002).
An epidemiological study by Knekt et al. (2002) of more than 10,000 Finnish men
and women showed intake of foods containing flavanoids was associated with lower risk
of type 2 diabetes. The study indicated the lower risk was associated with high intake of
quercetin. The same study also states that the strongest association between high flavonoid
intakes with lower risk for type 2 diabetes was seen when the source of flavonoids was
from apples and berries (Knekt et al., 2002). Therefore, a diet containing apples has the
potential to reduce risk of type 2 diabetes. Since apple is a common fruit with no known
side effects, any
α
-glucosidase-inhibiting effects, if found, are promising for type 2 diabetes
management.
16.3 Diabetes
Hyperglycemia has been linked to the onset of insulin-independent type 2 diabetes (Fonseca,
2003). A good strategy for management of type 2 diabetes is inhibition of enzymes that
hydrolyze dietary polysaccharides in the gut, which can significantly reduce the rise in blood
sugar levels after a meal by reducing the absorption of monosaccharides by the enterocytes
of the small intestine (Puls et al., 1977; Ratner, 2001). Enzymes that hydrolyze dietary
polysaccharides and modulate gut absorption are pancreatic
-glucosidases
(Harris and Zimmer, 1992; Bischoff, 1994). However, a common side effect of these enzyme
inhibitory drugs like acarbose is the excessive inhibition of pancreatic
α
-amylase and
α
-amylase, which
can result in abdominal distention, flatulence, and diarrhea (Puls and Keup, 1975; Bischoff
et al., 1985). These side effects are caused by abnormal fermentation of unhydrolyzed
polysaccharides by gut bacteria (Puls and Keup, 1975; Horii et al., 1987). Therefore, in
order to reduce these side effects but still manage hyperglycemia a high
α
α
-glucosidase
inhibition and low
-amylase inhibition is beneficial.
Acute complications in patients suffering from type 2 diabetes are generally
hyperglycemia-induced metabolic problems and infection. Long-term effects of hyper-
glycemia are microvascular complications like nephropathy, diabetic neuropathy, sex-
ual dysfunction, and retinopathy and the macrovascular complication of hypertension
(Nishikawa et al., 2000; Fig. 16.3). Recent studies have shown that hyperglycemia trig-
gers generation of free radicals in mesangial cells in the renal glomerulus, neuron cells in
peripheral nerves, and capillary endothelial cells in the retina (Brownlee, 2005). The gener-
ation of free radicals in all these cell types causes oxidative stress, which can be the cause of
microvascular complications generally linked with hyperglycemia (Brownlee, 2005). Most
cells are capable of reducing glucose transport inside the cell in hyperglycemic conditions
so as to maintain a constant internal glucose level; however, the cells usually damaged by
hyperglycemia were found to be inefficient in keeping their internal glucose levels constant
(Kaiser et al., 1993; Helig et al., 1995). Therefore, it is not only important to control post-
prandial hyperglycemia but also keep in check any cellular redox imbalances to prevent
diabetic complications.
α
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