Chemistry Reference
In-Depth Information
−1
−1
and
. reported the synthesis
of QDs with a water-soluble and paramagnetic Gd-based micellular
coating as molecular imaging probes for fluorescence microscopy
and MRI [58]. The core/shell CdSe/ZnS QDs exhibited excellent
optical properties. Coating the micellular and paramagnetic shell
rendered the nanoparticles magnetic resonance-detectable, water-
soluble, and biocompatible. Magnetic resonance results showed that
the nanoparticles had high
r
= 151 mM
s
at 4.7 T. Mulder
et al
2
relaxivities, which was three times
higher than that of Gd-DTPA (Fig. 5.3). Paramagnetic QDs were
later conjugated with cyclic arginine-glycine-aspartic acid (RGD)
peptides and were successfully targeted to human endothelial cells
in vitro
r
1
. This suggests that nanoparticulate bimodal agents may be
useful for the detection of tumor angiogenesis.
Figure 5.2
Molecular structure of the biotinylated Gd-DTPA (a) and
biotinylated Gd-wedge (b) structures with biotin (red) and Gd-
DTPA (blue) [56].
