Biomedical Engineering Reference
In-Depth Information
Figure 7.62
Calculated bursts of displaced analogs. Comparison with the case of desorption alone.
The general solution for an experiment with
i
successive bursts is
é
ù
i
-
1
+
-
-
β
c
(
t
-
t
)
-
-
k t
Õ
-
β
c
(
t
-
t
)
-
+
2
j
j
G = G
e
ê
e
j
ú
e
for
t
£ £
t
t
-
1
2
i
i
1
a
i
i
ê
ú
ë
j
=
1
û
(7.103)
é
ù
i
+
-
-
β
c
(
t
-
t
)
-
k t
Õ
+
2
j
j
G = G
e
ê
e
j
ú
for
t
>
t
-
1
1
a
i
ê
ú
ë
j
=
1
û
In Figure 7.62, we show a calculated kinetics of displaced analogs. In such a case,
the bursts of targets were all of the same concentration. The base line is the kinetics
of desorption of analogs alone (without the competition of the targets). The bursts
of displaced analogs are decreasing due to the fact that the immobilized concentra-
tion in analogs is decreasing.
In Figure 7.63, results of the model have been compared to experimental results
[35, 36]. In this case, different concentrations of targets (RDX) are changed. These
concentrations are clearly linked to the resulting displaced analogs concentrations.
Figure 7.63
Kinetic curves of displacement of RDX [36]. Comparison between experimental results
and calculated kinetics. The base line is the desorption of RDX analogs alone.
