Biomedical Engineering Reference
In-Depth Information
Figure 6.63  Schematic trajectories of two different types of cells or particles.
The larger the broadening rates w 2 / w 1 , the larger the separation distance after the
enlargement.
Figure 6.64 shows the result of a pinched channel system on the separation and
extraction of the largest cell population.
6.5.3  Deterministic Arrays—Deterministic Lateral Displacement (DLD)
Deterministic arrays are another type of microdevices for sorting out particles and
cells [27-30]. The principle of deterministic lateral displacement (DLD) is related to
the particle shifting of streamline caused by an obstacle. The principle is illustrated
in Figure 6.65. A small particle—or cell—slides between the rows of pillars and,
on average, follows a straight line. A large particle cannot slide between the pillars,
because it is trapped by its streamline and laterally shifted when approaching the pil-
lars. On average, it follows an oblique path. Hence, small and large particles do not
behave the same. A size threshold separates particles going straight and diagonally.
Figure  6.64  (a) Carrier flow before the pinched segment. (b) After the pinched flow system.
Reprinted with permission from [26]. Copyright 2008, American Chemical Society.
 
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