Biomedical Engineering Reference
In-Depth Information
Table 6
Parameters of the cornea of common animal models used in ocular research
Animal
Non-human
primates
Mice
Rat
Guinea pig
Rabbit
Cat
Dog
Pig
a
120
a
170
b
227.85 (
76
)
a
354
b
578
a
550 (
117
)
a
585 (
121
)
b
562
b
666 (
123
)
c
543 (
78
)
d
Western lowland
gorilla
a
580 (
124
)
Corneal thickness
(Central)
6(
117
)
e
122-137
f
(
118
)
5(
117
)
6(
117
)
64 (
13
)
a
545 (
117
)
a
592 (
121
)
h
600 (
122
)
b
407
μ
m
20 (
119
)
g
385 (
120
)
6.2 (
12
)
h
535 (
122
)
e
44.6
b
45.54 (
76
)
i
45.8
c
38 (
127
)
h
60 (
122
)
h
55 (
122
)
c
26 (
78
)
d
Western lowland
gorilla
c
33 (
124
)
Epithelial thickness
(Central) (
1.7 (
125
)
e
37.1-46.8
f
(
118
)
-
2.2 (
126
)
-
μ
m)
e
115.9
e
88 (
128
)
b
163.69 (
76
)
e
270 (
128
)
e
250 (
128
)
h
540 (
122
)
h
480 (
122
)
Stromal thickness
(Central) (
5.4 (
125
)
e
80.5-90.8
f
(
118
)
-
-
μ
m)
e
2.17
e
3.5 (
128
)
b
3.96 (
76
)
e
13 (
128
)
e
5.6 (
128
)
Descemet's membrane
thickness (Central)
(
0.3 (
118
)
-
10-15 (
129
)
-
Western lowland
gorilla
c
7.5 (
124
)
μ
m)
a
2,875 (
117
)
c
2,282-3,060 (
130
)
a
2,242 (
117
)
a
2,352 (
76
)
a
3,233 (
117
)
j
6,098 (
131
)
a
2,731 (
117
)
a
2,846 (
121
)
k
2,530 (
132
)
a
2,818 (
117
)
a
3,175 (
121
)
j
7,190 (
133
)
Endothelial cell
count (cells/m
2
)
-
Rhesus M
k
2,959-3,128
(
134
)
a
In vivo confocal microscopy
b
Ultrasound pachymetry
c
Light microscopy (for endothelium count cells: Flatmounts stained with alizarin red)
d
Primates studied:
L. mustelinus
,
C. torquatus
,
C. aethiops
,
C. cephus
,
E. patas
, Mirus,
P. troglodytes
,
G. gorilla
,
C. jacchus
,
A. caraya
,
A. paniscus
,
L. lagotricha
e
TEM
f
Mice strains studied: 129/SVJ; C
57
BL/6; BALB/C
g
AS-OCT
h
SD-OCT
i
Ultrahigh resolution OCT
j
SEM
k
Specular microscopy
