Biomedical Engineering Reference
In-Depth Information
Fig. 59 Ultrasound biomicroscopy of the anterior segment of a canine eye using
a 35 mHz transducer. C
¼
cornea, I
¼
iris, L
¼
lens, *
¼
iridocorneal angle
video capability, and effective imaging of patients who do not dilate
well. cSLOhas been used in several laboratory animal models [
124
].
When cSLO is combined with SD-OCT the combination provides
both en face and cross-sectional imaging of the retina [
124
].
3.11 Ultrasound
and Ultrasound
Biomicroscopy
Traditional ocular ultrasound uses frequencies ranging from 7.5 to
20 mHz and is used to image the entire globe and orbit. UBM
utilizes higher frequencies (35-50 mHz) to image the anterior
segment of the eye, specifically the cornea, iridocorneal angle, iris,
ciliary body, and lens (Fig.
59
)[
86
,
155
-
157
]. It can be used to
determine corneal thickness, document, and monitor changes in
the iridocorneal angle, ciliary cleft, angle opening distance, and
anterior chamber depth in response to various pharmacologic
agents and in studies of accommodation [
86
,
158
].
References
1. Munger RJ, Collins M (2013) Assessing ocu-
lar toxicity potential: basic theory and techni-
ques. In: Weir AB, Collins M (eds) Molecular
and integrative toxicology: assessing ocular
toxicology in laboratroy animals. Humana,
New York, pp 23-52
2. Novack GD (1994) Ocular toxicology. Curr
Opin Ophthalmol 5:110-114
3. Novack GD (1995) Ocular toxicology. Curr
Opin Ophthalmol 6:108-112
4. Novack GD (1997) Ocular toxicology. Curr
Opin Ophthalmol 8:88-92
5. Santaella RM, Fraunfelder FW (2007) Ocular
adverse effects associated with systemic medi-
cations: recognition and management. Drugs
67:75-93
6. Bill A (1975) Blood circulation and fluid
dynamics in the eye. Physiol Rev 55:383-417
7. Bellhorn R (1991) Laboratory animal oph-
thalmology. In: Gelatt KN (ed) Veterinary
ophthalmology, 2nd edn. Lea & Febiger, Phi-
ladelphia, PA, pp 656-679
8. Williams DL (2007) Laboratory animal oph-
thalmology. In: Gelatt KN (ed) Veterinary
