Biomedical Engineering Reference
In-Depth Information
Fig. 17 Corneal dystrophy in a Sprague-Dawley rat
Fig. 18 Corneal dystrophy in a Wistar rat
prevalence and severity by corneal exposure caused by desiccation,
sedation/anesthesia, orbital bleeding, environmental irritants, and
the test article itself.
The ophthalmologist must be familiar with what is normal for the
species in question and what are the common spontaneous
abnormalities for that species, age of animal, and breed/strain
[
39
]. Common laboratory species of interest may include mice,
rats, guinea pigs, cats, rabbits, dogs, Gottingen mini-pigs, and
NHPs (cynomolgus, rhesus). For the common laboratory species
2.4 Species-Specific
Ophthalmic Findings
