Biology Reference
In-Depth Information
Regulation of Base Excision
Repair in Eukaryotes by
Dynamic Localization
Strategies
Daniel B. Swartzlander,
*
,
{
Nicholas C. Bauer,
*
,
z
Anita
H. Corbett,
*
,
}
and Paul W.
Doetsch
*
,
}
,¶,||
*Department of Biochemistry, Emory
University School of Medicine, Atlanta,
Georgia, USA
{
Graduate Program in Genetics and
Molecular Biology, Emory University
School of Medicine, Atlanta, Georgia, USA
z
Graduate Program in Biochemistry, Cell,
and Developmental Biology, Emory
University School of Medicine, Atlanta,
Georgia, USA
}
Winship Cancer Institute, Emory
University School of Medicine, Atlanta,
Georgia, USA
¶
Department of Radiation Oncology,
Emory University School of Medicine,
Atlanta, Georgia, USA
||
Hematology and Medical Oncology, Emory
University School of Medicine, Atlanta,
Georgia, USA
I. Base Excision Repair . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
94
A. Requirements and Limitations of Base Excision Repair . . . . . . . . . . . . . . . . . . . . . .
94
B. Regulation of BER: Current Concepts and Observations . . . . . . . . . . . . . . . . . . . .
95
C. Dynamic Localization . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
100
II. Dynamic Localization of BER Proteins . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
102
A. General Pathway. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
102
B. Requirements to Dynamically Localize . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
102
C. Examples of Dynamic Localization in Response to Genotoxic Stress. . . . . .
103
D. Insight into Dynamic Localization. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
106
III. Hypotheses on the Orchestration of Dynamic Localization . . . . . . . . . . . . . . . . . . . . . .
107
References. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
109
This chapter discusses base excision repair (BER) and the known mecha-
nisms defined thus far regulating BER in eukaryotes. Unlike the situation with
nucleotide excision repair and double-strand break repair, little is known about
