Oxidized Base Damage and Single-Strand Break Repair in Mammalian Genomes: Role of Disordered Regions and Posttranslational Modifications in Early Enzymes - Progress in Molecular Biology - page 128

TABLE II
O XIDIZED DNA B ASE -S PECIFIC DNA G LYCOSYLASES IN M AMMALIAN C ELLS AND T HEIR P ROPERTIES

Enzyme/property OGG1 NTH1 NEIL1 NEIL2 NEIL3

Type Nth type Nei type

AP lyase b Elimination b Elimination bd Elimination bd Elimination b (weak bd ) elimination

3 0 dRP 3 0 dRP 3 0 P 3 0 P 3 0 dRP/3 0 P Product

Downstream Enzyme APE1 APE1 PNKP PNKP APE1/PNKP

DNA substrate Only duplex Only duplex Duplex, ss, bubble Duplex, ss, bubble Duplex, ss, bubble

Conserved motif HhH HhH H2TH H2TH H2TH

Presence of Zn finger None None Zn less finger Zn finger Zn finger (2)

Fe-S cluster None Fe-S cluster None None None

Catelytic residue Lys249 Lys212 Pro1 Pro1 Val1

Cell cycle-dependent expression None None S-phase specific None Unknown

Compiled from Refs. 8,9,11-13,28,32-35 .