Biology Reference
In-Depth Information
TABLE I (
Continued
)
Level of regulation
Protein
Organism
Gene
PTM
Protein interactions
Transcript level
Localization
Phos
132
SUMO
(K486)
133,134
Acetyl (K498,
K505, K508,
K521,
K524)
135
in response to ROS
136
Associated with LIG3, XRCC1,
POL
Nuc
130
Poly (ADP-ribose)
polymerase
Human
PARP1
Activity
"
-
,
and numerous non-
BER proteins
126,129,132,133,136
b
Nuc and Mito
139
Flap endonuclease
S. cerevisiae
RAD27
-
Associated with POL4 and
DNL4/LIF1
137
"
in G
1
-phase
"
in response to
alkylating agents
138
Human
FEN1
Phos
(Ser187)
140
Acetyl
141
Methyl
(R192)
142
Associated with PCNA, WRN,
CDK1, CDK2 NEIL1, LIG1,
p300, and APEX1
25,52,103,113-
115,131,140,141,143
"
in mitotic cycling
cells
Nuc and
Mito
145-147
in stationary cells
144
#
Ub (K164)
148
SUMO (K127,
K164)
148
Associated with APN2
95
Nuc
150
Proliferating cell
nuclear antigen
S. cerevisiae
POL30
"
in G
1
- and S-
phase
149
Ub (K164)
151
Acetyl
152
SUMO (K127,
K164)
148,153
in S phase
161,162
Nuc
112
Human
PCNA
Associated with MUTYH, p21,
POL
b
, XRCC1, FEN1, LIG1,
APEX1, and numerous non-
BER proteins
25,74,103,113-
115,121,154-160
"
"
PTM, posttranslational modification; Phos, phosphorylation; SUMO, sumoylation; Ub, ubiquitination; acetyl, acetylation; methyl, methylation; nitro, nitrosylation;
,
increases;
#
, decreases; Nuc, nuclear; Mito, mitochondrial.
