Biology Reference
In-Depth Information
TABLE I
E
UKARYOTIC
B
ASE
E
XCISION
R
EPAIR
P
ROTEINS AND
M
ECHANISMS OF THEIR
R
EGULATION
Level of regulation
Protein
Organism
Gene
PTM
Protein interactions
Transcript level
Localization
in G
1
-phase
19
Nuc and Mito
20
Uracil DNA
glycosylase
S. cerevisiae
UNG1
-
-
"
activity
22
Associated with RPA, XRCC1,
and PCNA
23-25
Human
UNG
Phos (Thr6,
Thr126)
21
APEX1
"
"
in G
1
- and S-
phase
26,27
Mitochondrial form
Nuc (UNG2)
and Mito
(UNG1)
Forms
28,29
"
in response to
ROS
28
activity
30
Nuc
31
SMUG1
-
APEX1
"
-
Nuc
34
3-methyl adenine
DNA glycosylase
S. cerevisiae
MAG1
-
-
"
in response to
alkylating agents
and UV
32,33
Acetyl
35
in G
1
-phase
26
Nuc
38
MPG
"
Human
Associated with hHR23,
XRCC1, and ER
a
35-37
SUMO
39
S. cerevisiae
NTG1
"
Endonuclease III/
thymine glycol
DNA glycosylase
-
in response to
menadione
40,41
Nuc and
Mito
39,42
SUMO
39
Associated with MLH1
43,44
Nuc
39,42
NTG2
-
activity
45
Associated with XPG, XRCC1,
and YB-1
36,46-48
Nuc and Mito
49-
51
Human
NTHL1
-
APEX1
"
"
in G
1
- and
S-phase
26,49
in S-phase
54
Nuc and Mito
55
Endonuclease
VIII-like
Human
NEIL1
-
Associated with FEN1 and
XRCC1
52,53
"
Nuc
57
NEIL2
Acetyl (Lys49,
Lys153)
56
Associated with p300 and
XRCC1
36,56
No cell cycle
dependence
57
Associated with RPA
58
Nuc
59
NEIL3
-
-
Nuc and Mito
60
8-oxoguanine DNA
glycosylase
S. cerevisiae
OGG1
-
-
-
activity
65,66
Associated with XRCC1
67
Human
hOGG1
Phos
(Ser326)
61,62
Acetyl (Lys41,
APEX1
"
No cell cycle
dependence
26
Nuc and
Mito
51,69
