Biology Reference
In-Depth Information
HO
Cholesterol
DAF-36
HO
7-Dehydrocholesterol
HO
H
Lathosterol
DHS-16
O
O
H
Cholest-4-en-3one
Lathosterone
DAF-9
DAF-9
O
O
OH
OH
O
O
H
4
-Dafachronic acid
Figure 7.2 DA biosynthesis. Proposed pathways for D-7 and D-4 DA production, with
identified activities DAF-36/Rieske, DHS-16/3HSD, and DAF-9/CYP27A1 shown (see text).
7
-Dafachronic acid
D
D
evidence for this has remained elusive (
Patel et al., 2008
) possibly because of
vanishingly small quantities of this ligand or that HSD-1 affects other aspects
of biosynthesis. In fact, recent evidence suggests there may be other DAs and
that the biosynthetic pathways are more complex than previously thought
(
Wollam et al., 2012
). Importantly, despite gaps in our knowledge, the
