Biology Reference
In-Depth Information
CHAPTER SEVEN
Steroid Regulation of C. elegans
Diapause, Developmental Timing,
and Longevity
,†,
{
,1
*
Max Planck Institute for Biology of Ageing, Cologne, Germany
†
Adam Antebi
*
Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases (CECAD), University
of Cologne, Cologne, Germany
{
Department of Molecular and Cellular Biology, Huffington Center on Aging, Baylor College of Medicine,
Houston, Texas, USA
1
Corresponding author: e-mail address: AAntebi@age.mpg.de
Contents
1.
Introduction
182
1.1 Hormonal regulation of maturation
182
2. Endocrine Regulation of the Dauer Diapause
183
2.1 C. elegans life history
183
2.2 A hormone-regulated switch governs the dauer decision
183
2.3 DA biosynthetic pathway
186
2.4 DA production is distributed
189
2.5 DA signal amplification enforces reproductive commitments
190
3. DAF-12 Regulates Developmental Timing
192
3.1 Heterochronic genes
192
3.2 The microRNA paradigm
192
3.3 DAF-12 regulates the let-7 microRNAs
193
3.4 DAF-12 targets include heterochronic genes
195
3.5 daf-12 is feedback regulated by the let-7 microRNAs
196
3.6 daf-12 acts in opposition to lin-42/period
196
3.7 Dauer reprogramming
198
3.8 Heterochronic genes and the molt cycle
198
4. Hormonal Control of Longevity
201
4.1 Gonadal longevity pathway
201
5. Perspectives
203
Acknowledgments
205
References
205
