Recent Applications in Capillary Electrochromatography - Chiral Separations by Capillary Electrophoresis - page 459

15

Recent Applications
in Capillary
Electrochromatography

Debby Mangelings and Yvan Vander Heyden

CONTENTS
15.1 Introduction ................................................................................................. 459
15.2 Enantioseparations in Regular Capillary
Electrochromatographic Mode ................................................................... 461
15.2.1 Separations on Particle-Based Stationary Phases.......................... 461
15.2.2 Separations on Monolithic Stationary Phases ............................... 478
15.3 Enantioseparations in Pressurized Capillary
Electrochromatographic Mode ................................................................... 481
15.3.1 Separations on Particle-Based Stationary Phases.......................... 481
15.3.2 Separations on Monolithic Stationary Phases ............................... 486
15.4 Enantioseparations in Open-Tubular Capillary Electrochromatography.... 486
15.5 Enantioseparations in Chip Capillary Electrochromatography .................. 489
15.6 Concluding Remarks................................................................................... 490
Acknowledgment ................................................................................................... 492
List of Abbreviations.............................................................................................. 492
References .............................................................................................................. 493

15.1 INTRODUCTION
Capillary electrochromatography (CEC) is a separation technique that theoretically
combines the advantages of both liquid chromatography (LC) and capillary electro-
phoresis (CE). Due to the presence of a stationary phase (SP) inside a capillary and
the use of an electro-osmotic l ow (EOF) as a driving force for the mobile phase,
the user can benei t from properties, such as a high sample loading capacity, high
efi ciencies, high peak capacities, and low sample and solvent consumptions [1].
Since its introduction as separation technique in the early 1970s [2], many appli-
cations have been developed in CEC. These applications i nd their origin from a
variety of research areas, such as environmental analysis, food and natural products
analysis, industrial analysis, forensic analysis, and pharmaceutical and biomedical

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