Macrocyclic Antibiotics as Chiral Selectors - Chiral Separations by Capillary Electrophoresis - page 117

TABLE 5.1
Use of Antibiotics as Chiral Selectors in Capillary Zone Electrophoresis
Compounds Chiral Selector BGE Ref.

Ala-Ala, Ala-Gly, Ala-Gly-Gly, Ala-Leu, Gly-Ala,
Gly-Asn, Gly-Asp, Gly-Leu, Gly-Met, Gly-Phe, Gly-Val,
Leu-Ala, Leu-Gly, Leu-Gly-Gly Leu-Leu

Vancomycin (1 mM)
Teicoplanin (1 mM)

50 mM phosphate buffer pH 7.5, 10%
isopropanol 12.5 mM phosphate + 12.5 mM
acetate-tris buffer, 40% ACN

[35]

Carprofen, l urbiprofen, ketoprofen, naproxen, ibuprofen,
2

Vancomycin (5-12 mM) (partial i lling) 50 mM acetic acid-ammonium acetate buffer

pH 4.8 CE-MS

[41]

-hydroxyibuprofen, carboxy-ibuprofen, etodolac,
etodolacglucuronide, 7-hydroxyetodolac,
7-hydroxyetodolac-glucuronide

′

FMOC-(Ala, Asn, Asp, Glu, Isoleu, Leu, Met, Norleu,
Norval, Phe, Pro, Ser, Val), ketoprofen, dimetoxy-5,6,5′6′-
bismethylenedioxybiphenyl- 2,3′-dicarboxylic acid
(DBDA)

Vancomycin (2 mM) 50 mM Tris-phosphate buffer pH 6.0, 0.002%

(w/v) HDB (co-electroosmotic l ow)

[59]

Carprofen, cicloprofen, fenoprofen, l urbiprofen, ibuprofen,
ketoprofen, indoprofen, naproxen, suprofen, loxiglumide,
acenocoumarol, warfarin dichlorprop, diclofop acid,
fenoprop, fenoxaprop acid, l amprop acid, l uazifop acid,
haloxyfop acid, mecoprop

(Hepta-Tyr) (1-3 mg/mL) (partial
i lling)

50 mM Britton Robinson buffer pH 5, 20%
ACN (polyacrylamide-coated capillary)

[47]

Carprofen, fenoprofen, l urbiprofen, indoprofen,
ketoprofen, suprofen

Actaplanin A (0.5 mM) 40 mM phosphate buffer pH 6, 15%-30%

2-methoxyethanol

[21]

Avoparcin (0.4 mM)
Ristocetin A (0.4 mM)
Teicoplanin (0.4 mM)
Vancomycin (0.4 mM)

50 mM phosphate buffer pH 6 [22]

N -3,5-Dinitrobenzoyl-alanine, 2-aminoadipic acid, α-amino-
n -butyric acid, β-amino- n -caprylic acid, α-amino-
n -butyric acid, 3-amino-3-phenylpropionic acid,
α-amino-1-thiopheneacetic acid, aspartic acid, ethionine,
o -l uorophenylglycine, glutamic acid, homoserine,
isoleucine, leucine, methionine, norleucine, norvaline,
serine, valine

( continued )