Biomedical Engineering Reference
In-Depth Information
D
V
¼ D
x
D
y
(3.48a)
A e ¼
A w ¼ D
y
(3.48b)
A n ¼
A s ¼ D
x
:
(3.48c)
The diffusion coefficients at the interface in Eqn (3.47), i.e.,
G s , are determined using
a harmonic mean approach. Upon substitution of Eqns (3.45) and (3.46) into Eqn (3.43) , we have
r P F P r P F
G e ,
G w ,
G n , and
P D
o
V
t
þF e F P þðF P F E ÞkF e ; 0
D
k F w F P þðF P F W ÞkF w ; 0
k
(3.49)
þF n F P þðF P F N ÞkF n ; 0 kF s F P þðF P F S ÞkF s ; 0 k
¼ D e ðF E F P ÞD w ðF P F W ÞþD n ðF N F P ÞD s ðF P F S ÞþðS C þ S P F P ÞDV
or, upon rearrangement,
r P F
P DV
D
r P F P D V
D
t þð
F e
F w þ
F n
F s ÞF P
t
þðF P F E ÞkF e ; 0
k þðF P F W ÞkF w ; 0
k
(3.50)
þðF P F N ÞkF n ;
k
¼ D e ðF E F P ÞD w ðF P F W ÞþD n ðF N F P ÞD s ðF P F S ÞþðS C þ S P F P ÞDV:
0
k þðF P F S ÞkF s ;
0
To enforce continuity, the continuity equation has to be considered in the discretization of the general
transport equation. For this purpose, the continuity equation (Eqn 3.3 ) is similarly integrated over the
CV to give
ðr P r P ÞD
V
þ
F e
F w þ
F n
F s ¼
0
(3.51a)
D
t
and, upon multiplication by F P ,
r P F P D
r P F P D
V
V
t þð
F e
F w þ
F n
F s ÞF P ¼
0
:
(3.51b)
D
t
D
Subtracting equation (3.51b) from Eqn (3.50) results in
r P F P D
r P F
o
V
P D
V
D
t
D
t
þðF P F E Þk
F e ;
0
k þðF P F W Þk
F w ;
0
k
(3.52)
þðF P F N Þk
F n ;
0
k þðF P F S Þk
F s ;
0
k
¼
D e ðF E F P Þ
D w ðF P F W Þþ
D n ðF N F P Þ
D s ðF P F S Þþð
S C þ
S P F P ÞD
V
and, upon rearrangement, gives the final discretized equation for the general transport equation in
a compact form as
a P F P ¼ a E F E þ a W F W þ a N F N þ a S F S þ b
(3.53a)
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