Biomedical Engineering Reference
In-Depth Information
D
V
¼ D
x
D
y
(3.48a)
A
e
¼
A
w
¼ D
y
(3.48b)
A
n
¼
A
s
¼ D
x
:
(3.48c)
The diffusion coefficients at the interface in Eqn (3.47), i.e.,
G
s
, are determined using
a harmonic mean approach. Upon substitution of Eqns (3.45) and (3.46) into Eqn
(3.43)
, we have
r
P
F
P
r
P
F
G
e
,
G
w
,
G
n
, and
P
D
o
V
t
þF
e
F
P
þðF
P
F
E
ÞkF
e
;
0
D
k F
w
F
P
þðF
P
F
W
ÞkF
w
;
0
k
(3.49)
þF
n
F
P
þðF
P
F
N
ÞkF
n
;
0
kF
s
F
P
þðF
P
F
S
ÞkF
s
;
0
k
¼ D
e
ðF
E
F
P
ÞD
w
ðF
P
F
W
ÞþD
n
ðF
N
F
P
ÞD
s
ðF
P
F
S
ÞþðS
C
þ S
P
F
P
ÞDV
or, upon rearrangement,
r
P
F
P
DV
D
r
P
F
P
D
V
D
t
þð
F
e
F
w
þ
F
n
F
s
ÞF
P
t
þðF
P
F
E
ÞkF
e
;
0
k þðF
P
F
W
ÞkF
w
;
0
k
(3.50)
þðF
P
F
N
ÞkF
n
;
k
¼ D
e
ðF
E
F
P
ÞD
w
ðF
P
F
W
ÞþD
n
ðF
N
F
P
ÞD
s
ðF
P
F
S
ÞþðS
C
þ S
P
F
P
ÞDV:
0
k þðF
P
F
S
ÞkF
s
;
0
To enforce continuity, the continuity equation has to be considered in the discretization of the general
transport equation. For this purpose, the continuity equation (Eqn
3.3
) is similarly integrated over the
CV to give
ðr
P
r
P
ÞD
V
þ
F
e
F
w
þ
F
n
F
s
¼
0
(3.51a)
D
t
and, upon multiplication by
F
P
,
r
P
F
P
D
r
P
F
P
D
V
V
t
þð
F
e
F
w
þ
F
n
F
s
ÞF
P
¼
0
:
(3.51b)
D
t
D
Subtracting equation
(3.51b)
from Eqn
(3.50)
results in
r
P
F
P
D
r
P
F
o
V
P
D
V
D
t
D
t
þðF
P
F
E
Þk
F
e
;
0
k þðF
P
F
W
Þk
F
w
;
0
k
(3.52)
þðF
P
F
N
Þk
F
n
;
0
k þðF
P
F
S
Þk
F
s
;
0
k
¼
D
e
ðF
E
F
P
Þ
D
w
ðF
P
F
W
Þþ
D
n
ðF
N
F
P
Þ
D
s
ðF
P
F
S
Þþð
S
C
þ
S
P
F
P
ÞD
V
and, upon rearrangement, gives the final discretized equation for the general transport equation in
a compact form as
a
P
F
P
¼ a
E
F
E
þ a
W
F
W
þ a
N
F
N
þ a
S
F
S
þ b
(3.53a)
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