Biomedical Engineering Reference
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Secondary transverse flow generated by slanted ridges on the channel wall can be used for
designing chaotic advection in microchannels. Stroock et al.
[25,26]
proposed a mixer design with
a pair of slated ridges called the staggered herringbone mixer (SHM;
Figure 6.21
). These structures
generate a pair of counter-rotating vortices. The flow pattern changes within a mixing unit; thus, both
rotational and extensional secondary flows are available in a mixing unit. Repeating these rotational
and extensional flows leads to chaotic advection. The mixing efficiency is determined by the asym-
metry of the herringbone structure
p ¼W
1
/
W
and the number of ridges for a particular flow pattern. At
the optimal angle of 45
, the number of ridges determines the angular displacement per half cycle
DF
half cycle
. The flow in the mixing channel is not chaotic if
p
0
.For
p ¼
2/3
1/2 and
DF
half cycle
/
/
60
, chaotic advection occurs in the mixing channel.
Figure 6.22
shows the typical
concentration distribution inside a staggered herringbone mixer. The counter-rotating vortices stretch
and fold the mixing liquids, reducing the striation thickness significantly.
A number of numerical works have been reported on the optimization of the mixers depicted in
Figs. 6.19 and 6.21
. Sch¨nfeld and Hardt
[29]
numerically investigated the helical flows of the mixer
shown in
Fig. 6.19
. The strength of the vortices or the change of angular displacement is proportional
to the square of the relative height
a
of the ridge height as predicted with equation
(6.9)
. Furthermore,
the simulation results confirm that the flow pattern is almost independent of the Reynolds number.
Thus, the mixing concept based on slanted ridges on a channel wall can work with a wide range of
Reynolds number. The change of angular displacement almost doubles with ridges on both top and
bottom walls of the mixing channel. Hassel and Zimmerman
[30]
investigated the SHM design. Kang
and Kwon
[31]
used the so-called colored particle tracking method (CPTM) to investigate both the
helical design and the SHM design. The method first runs a flow analysis to obtain the periodic velocity
and
DF
half cycle
>
FIGURE 6.21
Micromixer with staggered herringbone (SHB) structure.
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