Biomedical Engineering Reference
In-Depth Information
FIGURE 5.8
Concept of sequential lamination.
where the dimensionless space variable
x
* and time
t
* are defined as
x
x
*
¼
(5.11)
w
ð
t
Þ
and
Z
t
D
wðt
0
Þ
2
d
t
0
:
t
*
¼
(5.12)
0
t
*
1/2
. Thus, the relation for the
The penetration distance
d
in the (
x
*,
t
*) space is given by
dx
*
w
penetration distance
d
x
in the (
x
,
t
) space is
D
W
2
2
a
ð
1
2
d
x
W
exp
Þ
¼
exp 2
at
1
Þ
:
(5.13)
ð
at
Mixing is complete if
d
x
¼
W
final
when the diffusive penetration distance is on the same order of the
striation thickness:
D
W
2
2
a
ð
1
2
1
¼
exp 2
at
1
Þ
:
(5.14)
The value of
a
is inversely proportional to the shear rate
afu=W
; thus, Pe
W
f aW
2
/
D
. At the fully
mixed state [exp(2
at
final
)
[
1], the required channel length of the mixer would be
L
mixer
W
f
ln Pe
W
:
(5.15)
The transformations described above can be achieved either by sequential lamination or by chaotic
advection. Sequential lamination can be implemented by forced splitting and lamination or by chaotic
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