Biopolyesters in Tissue Engineering Applications - Advances in Polymer Science - page 38

Fig. 14 In vitro degradation (pH 7.4, 37 ◦ C) of solution-cast P3HB, P3HB-18%4HB, and
P4HB films. a Molecular weight and b sample mass vs. degradation time [51]
ated hydrolysis in these experiments [167, 267], and the molecular weights M n
of P3HB-9%4HB and P3HB-16%4HB films reached approximately 60%and
40%, respectively, after 160 days in buffer solution (37 ◦ C, pH 7.4), compared
to 80% for the P3HB homopolymer [167].
In Vivo Degradation
The complete resorption of P4HB within 8 weeks has been reported when
used as coating layer for a PGA heart valve scaffold in sheep [43]. A porous