Biomedical Engineering Reference
In-Depth Information
Fig. 11
30) patches implanted
on the intestinal wall of rats [38]; in vitro degradation (pH 7.4, 37
◦
C) for comparison.
b
In vivo degradation of solution-cast P3HB and P3HB/at-P3HB (70
a
In vivo degradation of solution-cast P3HB/at-P3HB (70
/
/
30) patches im-
planted to cover skull defects in minipigs [72]
P3HB films were tested subperiostally on the osseus skull of rabbits. Al-
though there were no macroscopic signs of resorption after 20 months of
implantation, no remaining test body could be found after 25 months [208].
Patches made of P3HB and P3HB/at-P3HB (70
30) blends have been used
to cover skull defects in minipigs and a strongly enhanced degradation of
the patch containing at-P3HB has been observed (Fig. 11b) [72]. An amount
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