Biomedical Engineering Reference
In-Depth Information
Fig. 9 a In vitro degradation (pH 7.4, 37 C) of solution-cast P3HB films, compared to that
of P3HB films modified with 30% each of at-P3HB, dg-P3HB ( M w = 3000), TEC (leached),
and BTHC; PLLA films for comparison. After 2 years in buffer solution, significant
mass loss was observed only for films made of P3HB/at-P3HB (12%) and P3HB/BTHC
(10%) [38]. b Effect of increasing amount of at-P3HB in P3HB/at-P3HB blends on the in
vitro degradation (pH 7.4, 37 C) of solution-cast films. There was no mass loss of P3HB
films after 2 years in buffer solution while mass loss of P3HB/at-P3HB films increased
with increasing amount of at-P3HB (30
70: 12%, 50
50: 18%, 70
30: 29%) [39]
blend showed accelerated mass loss with bulk and surface erosion after incu-
bation in newborn calf serum or pancreatin solution compared to plain buffer
solution. This was attributed to the effects of enzyme activity over and above
simple ester hydrolysis [172]. The potential participation of enzymes found
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